C-reactive protein: Marker of poor prognosis in ST-elevation myocardial infarction (STEMI) patients?

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Recent evidence suggests that C-reactive peptide (CRP) may play an important role as a marker unstable atheromatous plaque and acute coronary syndrome (ACS). A recent retrospective study involving 102,337 ACS patients found CRP elevation resulted in significant increase short- long- term mortality. This association present opportunity to improve patient selection for therapeutics such immunomodulatory drugs targeting inflammation hence, reducing cardiovascular events. Purpose To determine the prognostic value presenting with ST-elevation myocardial infarction (STEMI). Methods All which presented STEMI 2016 2017 were included this retrospective, observational study. Exclusion criteria who did not have taken at point contact hospital prior PPCI, treated conservatively (no PPCI), any condition levels regardless (active inflammatory disease, infective process, or malignancy). data was collected from online systems. Prognosis evaluated based on major adverse events (unstable angina requiring hospitalisation, [MI], hospitalisation due pulmonary oedema revascularization repeat PCI artery bypass [CABG]) all-cause Patients followed up till September 2022, maintaining minimum 5-year follow up. stratified into 3 groups according levels; Group 1: 0-5mg/L (normal), 2: 5-15mg/L 3: ≥15mg/L. Chi-square used statistical analysis categorical data. Kruskal–Wallis 1-way variance test continuous after finding non-normal distribution. P <0.05 considered significant. Results 438 our 2017. total 185 excluded no available. further 13 they noted ongoing malignancy, condition. 2 undergo PPCI. The remaining cohort 238 distributed per Figure 1. Baseline characteristics collected; statistically differences (Figure 1). Statistically more MACEs deaths higher (apart CABG) Kaplan-Meier curves time-to-first MACE cumulative survival indicated poorer outcome (p<0.0001 p=0.0004, respectively) 2). Conclusion Higher PPCI has been shown be related prognosis STEMI. Further prospective work is required explore pathway ischaemic heart disease patients.